Document Details

Document Type : Article In Journal 
Document Title :
Facile One-Step Micropatterning Using Photodegradable Gelatin Hydrogels for Improved Cardiomyocyte Organization and Alignment
Facile One-Step Micropatterning Using Photodegradable Gelatin Hydrogels for Improved Cardiomyocyte Organization and Alignment
 
Subject : physics 
Document Language : English 
Abstract : Hydrogels are often employed as temporary platforms for cell proliferation and tissue organization in vitro. Researchers have incorporated photodegradable (PD) moieties into synthetic polymeric hydrogels as a means of achieving spatiotemporal control over material properties. In this study protein-based PD hydrogels composed of methacrylated gelatin and a crosslinker containing o-nitrobenzyl ester groups are developed. The hydrogels are able to degrade rapidly and specifically in response to UV light and can be photopatterned to a variety of shapes and dimensions in a one-step process. Micropatterned PD hydrogels are shown to improve cell distribution, alignment, and beating regularity of cultured neonatal rat cardiomyocytes. Overall this work introduces a new class of PD hydrogel based on natural and biofunctional polymers as cell culture substrates for improving cellular organization and function. 
ISSN : 1616-301X 
Journal Name : ADVANCED FUNCTIONAL MATERIALS 
Volume : 25 
Issue Number : 6 
Publishing Year : 1435 AH
2015 AD 
Article Type : Article 
Added Date : Monday, August 21, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
KMC TsangTsang, KMC InvestigatorDoctorate 
N AnnabiAnnabi, N ResearcherDoctorate 
F ErcoleErcole, F ResearcherDoctorate 
k ZhouZhou, k Researcher  
D.J KarstKarst, D.J ResearcherDoctorate 
F.Y LiLi, F.Y ResearcherDoctorate 
J.M HaynesHaynes, J.M ResearcherDoctorate 
R.A EvansEvans, R.A ResearcherDoctorate 
H Thissen,Thissen,, H ResearcherDoctorate 
A KhademhosseiniKhademhosseini, A ResearcherDoctoratealik@rics.bwh.harvard.edu

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