Document Details Document Type : Article In Journal  Document Title : Effect of melittin on mice stomach Effect of melittin on mice stomach   Document Language : English  Abstract : Melittin, the main bee venom component, has many positive biological effects and a relatively low toxicity in various cell types. However, there is no evidence of the effect of melittin on gastrointestinal cells. In the present study, we investigated the histological and immuonohistochemical effects of melittin on mice stomach. Adult male mice (Albino Swiss) were randomly divided into two groups (7 mice for each group): control group and melittin only treated group (10 and 40 mu g/kg). These mice were sacrificed, then samples from the stomach were collected and prepared for histopathological studies by using alcian blue stain and immuonohistochemical studies by using smooth muscle actin (SMA) antibody. Treatment with melittin alone do not cause any harmful effect on the stomach tissue where the microscopic examination of Alcian blue stained section showed the normal distribution of the mucous secreting cells of the stomach tissues. On other hand, no changes were observed on smooth muscle cells. This study demonstrated the safety of using melittin on gastrointestinal tissues if used in definite dose and for suitable duration, which offers an opportunity for its use as a treatment for many diseases of the gastrointestinal tract. (C) 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University.  ISSN : 1319-562X  Journal Name : SAUDI JOURNAL OF BIOLOGICAL SCIENCES  Volume : 21  Issue Number : 1  Publishing Year : 1435 AH 2014 AD  Article Type : Article  Added Date : Thursday, August 10, 2017  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email Osama Abu-Zinadah Abu-Zinadah, Osama Researcher     Tarek Rahmy Rahmy, Tarek Researcher     Abeer Alahmari Alahmari, Abeer Researcher     Faiza Abdu Abdu, Faiza Researcher     Files File Name Type Description  42559.pdf pdf   Back To Researches Page