Document Details

Document Type : Article In Journal 
Document Title :
Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering
Reduced Graphene Oxide-GelMA Hybrid Hydrogels as Scaffolds for Cardiac Tissue Engineering
 
Subject : physics 
Document Language : English 
Abstract : Biomaterials currently used in cardiac tissue engineering have certain limitations, such as lack of electrical conductivity and appropriate mechanical properties, which are two parameters playing a key role in regulating cardiac cell behavior. Here, the myocardial tissue constructs are engineered based on reduced graphene oxide (rGO)-incorporated gelatin methacryloyl (GelMA) hybrid hydrogels. The incorporation of rGO into the GelMA matrix significantly enhances the electrical conductivity and mechanical properties of the material. Moreover, cells cultured on composite rGO-GelMA scaffolds exhibit better biological activities such as cell viability, proliferation, and maturation compared to ones cultured on GelMA hydrogels. Cardiomyocytes show stronger contractility and faster spontaneous beating rate on rGO-GelMA hydrogel sheets compared to those on pristine GelMA hydrogels, as well as GO-GelMA hydrogel sheets with similar mechanical property and particle concentration. Our strategy of integrating rGO within a biocompatible hydrogel is expected to be broadly applicable for future biomaterial designs to improve tissue engineering outcomes. The engineered cardiac tissue constructs using rGO incorporated hybrid hydrogels can potentially provide high-fidelity tissue models for drug studies and the investigations of cardiac tissue development and/or disease processes in vitro 
ISSN : 1613-6810 
Journal Name : SMALL 
Volume : 12 
Issue Number : 27 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Wednesday, August 9, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
S.R Shin,Shin,, S.R InvestigatorDoctorate 
C ZihlmannZihlmann, C ResearcherDoctorate 
M AkbariAkbari, M ResearcherDoctorate 
k ZhangZhang, k ResearcherDoctorate 
P AssawesAssawes, P ResearcherDoctorate 
C CheungCheung, C ResearcherDoctorate 
V ManoharanManoharan, V ResearcherDoctorate 
Y.S ZhangZhang, Y.S ResearcherDoctorate 
M YuksekkayaYuksekkaya, M Researcher  

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