Document Details

Document Type : Article In Journal 
Document Title :
Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation
Genome-wide association study of the plasma triglyceride response to an n-3 polyunsaturated fatty acid supplementation
 
Document Language : English 
Abstract : Studies have shown a large interindividual variability in plasma TG response to long-chain n-3 PUFA supplementation, which may likely be attributable to genetic variability within the populations studied. The objective is to compare the frequency of SNPs in a genome-wide association study between responders (reduction in plasma TG levels >= 0.01 mM) and nonresponders (increase in plasma TG of >= 0 mM) to supplementation. Genomic DNA from 141 subjects who completed a 2-week run-in period followed by 6-week supplementation with 5 g of fish oil daily (1.9-2.2 g EPA and 1.1 g DHA daily) were genotyped on Illumina HumanOmni-5-QuadBeadChip. Thirteen loci had frequency differences between responders and nonresponders (P < 1 x 10(-5)), including SNPs in or near IQCJ-SCHIP1, MYB, NELL1, NXPH1, PHF17, and SLIT2 genes. A genetic risk score (GRS) was constructed by summing the number of risk alleles. This GRS explained 21.53% of the variation in TG response to n-3 PUFA supplementation when adjusted for age, sex, and BMI (P = 0.0002). Using Fish Oil Intervention and Genotype as a replication cohort, the GRS was able to explain 2% of variation in TG response when adjusted. In conclusion, subjects who decrease their plasma TG levels following n-3 PUFA supplementation may have a different genetic profile than individuals who do not respond. 
ISSN : 0022-2275 
Journal Name : JOURNAL OF LIPID RESEARCH 
Volume : 55 
Issue Number : 7 
Publishing Year : 1435 AH
2014 AD 
Article Type : Article 
Added Date : Wednesday, August 2, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Iwona RudkowskaRudkowska, Iwona Researcher  
Frederic GuenardGuenard, Frederic Researcher  
Pierre JulienJulien, Pierre Researcher  
Patrick CoutureCouture, Patrick Researcher  
Simone LemieuxLemieux, Simone Researcher  
Olivier BarbierBarbier, Olivier Researcher  
Philip CalderCalder, Philip Researcher  
Anne MinihaneMinihane, Anne Researcher  
Marie-Claude VohlVohl, Marie-Claude Researcher  

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