Document Details Document Type : Article In Journal  Document Title : Efficacy of some synthesized thiazoles against dermatophytes Efficacy of some synthesized thiazoles against dermatophytes   Document Language : English  Abstract : Twelve thiazoles and their fused derivatives were tested for their antimicrobial activity against Trichophyton rubrum, T terrestre, Epidermophyton floccosum, and Microsporum gypseum. Most of the synthesized compounds were inhibitory to the tested fungi. The most effective compound was 5-(4-ethoxybenzylidene-4,5-dihydro-4-oxothiazol-2-yl)-N,3-diphenylbut-2-namide (3c) followed by 2-(4-oxo-4,5-dihydrothiazol-2-yl)-3-phenyl-but-2-enoic acid-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-amide (2b). These compounds were more efficacious than terbinafine, the reference drug. The tested compounds caused variable reduction in the activity of keratinase of the dermatophytes, depending on the azole derivative and the test fungus. Thiazole derivatives (2b) and (3c) exhibited the highest efficacy in decreasing ergosterol biosynthesis of the tested dermatophytes. The treatment of guinea pigs with compound (3c) induced complete curing in the case of all the test dermatophytes 30 days post-treatment. The percent curing for compounds (3c) and (2b) was better than the reference drug.  ISSN : 1156-5233  Journal Name : JOURNAL DE MYCOLOGIE MEDICALE  Volume : 23  Issue Number : 4  Publishing Year : 1434 AH 2013 AD  Article Type : Article  Added Date : Sunday, July 23, 2017  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email S Ouf Ouf, S Researcher     A Abu Taleb Abu Taleb, A Researcher     N Tharwat Tharwat, N Researcher     N Geweely Geweely, N Researcher     Files File Name Type Description  42197.pdf pdf   Back To Researches Page