Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Synthesis and antiinflammatory evaluation of some more new 1,2,4-triazolo[3,4-b] thiadiazoles as an antimicrobial agent: Part-I Synthesis and antiinflammatory evaluation of some more new 1,2,4-triazolo[3,4-b] thiadiazoles as an antimicrobial agent: Part-I |
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Subject |
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Chemistry |
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Document Language |
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English |
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Abstract |
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Some of the new 1,2,4-triazolothiadiazole derivatives (2-9) have been synthesized starting from the interaction between 4-amino-3-(pyrid-4yl)-5- mercapto-1,2,4-triazole(1) and α, α,β,-bifunctional compounds, such as tri ethylphosphite, trifluroacetamide, cyanamide, isolthiocyante, carbon disulfide and /or fluorinated aromatic aldehydes in different conditions. The new semi-drugs 5-substituted amino-4-amino-3-(pyrid-4y)1,2,4-triazoles(10a,10b) were also obtained from treatment of compound1 with 4-fluoroanline and sulfa-drug as sulfathiazole. Structure of the products have been established on the basis of their elemental analysis and spectral (UV, IR, 1HNAR, 13Cnmr and mass) data. The novel molecules synthesized were evaluated for their anti-inflammatory and antimicrobial behavior in comparison with Indomethacin (Anti-inflammatory), Nalidexic acid (bacteria) and Nystain (fungi) as antibiotics, Where the compounds 3,7b and 9exhibited higher activities. |
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ISSN |
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0974-4290 |
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Journal Name |
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International Journal of ChemTech Research |
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Volume |
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3 |
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Issue Number |
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1 |
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Publishing Year |
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1432 AH
2011 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, June 16, 2012 |
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Researchers
| رضا محمدي عبدالرحمن | Abdel-Rahman, Reda Mohammady | Researcher | Doctorate | r-mrahman1951@yahoo.com |
| خالد عمر الفوتي | Al-Footy, Khalid Omar | Researcher | Doctorate | kalfooti@kau.edu.sa |
| F M Aqlan | Aqlan, F M | Researcher | Doctorate | |
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