Document Details

Document Type : Article In Journal 
Document Title :
Benzotriazole reagents for the syntheses of Fmoc-, Boc-, and Alloc-protected amino acids
Benzotriazole reagents for the syntheses of Fmoc-, Boc-, and Alloc-protected amino acids
 
Subject : Chemistry 
Document Language : English 
Abstract : Stable Fmoc-, Boc-, and Alloc-benzotriazoles react with various amino acids including unprotected serine and glutamic acid, in the presence of triethylamine at 20° as reagents to introduce -amino protecting groups to afford Fmoc-, Boc-, and Alloc-protected amino acids (77-94%) free of dipeptide and tripeptide impurities. Fmoc-, and Alloc-Gly-Gly-OH dipeptides were prepared in 90% yields by N-acylation of glycylglycine with Fmoc- and Alloc-benzotriazoles in the presence of triethylamine. Synthesized N-protected amino acids were greater than 99% pure, analyzed by HPLC. 
ISSN : 0936-5214 
Journal Name : Synlett 
Volume : 14 
Issue Number : 1 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Tuesday, May 1, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Tarek S IbrahimIbrahim, Tarek SResearcherDoctorate 
Srinivasa R TalaTala, Srinivasa RResearcherDoctorate 
Said A El-FekyEl-Feky, Said AResearcherDoctorate 
Zakaria K Abdel-SamiiAbdel-Samii, Zakaria KResearcherDoctorate 
Alan Roy KatritzkyKatritzky, Alan RoyResearcherDoctoratekatritzky@chem.ufl.edu

Files

File NameTypeDescription
 33078.pdf pdfAbstract

Back To Researches Page