Document Details

Document Type : Article In Journal 
Document Title :
Aurantoside J: A new tetramic acid glycoside from Theonella swinhoei. Insights into the antifungal potential of aurantosides
Aurantoside J: A new tetramic acid glycoside from Theonella swinhoei. Insights into the antifungal potential of aurantosides
 
Subject : Chemistry 
Document Language : English 
Abstract : The chemical investigation of an Indonesian specimen of Theonella swinhoei afforded four aurantosides, one of which, aurantoside J (5), is a new compound. The structure of this metabolite, exhibiting the unprecedented N-α-glycosidic linkage between the pentose and the tetramate units, has been determined through detailed spectroscopic analysis. The four obtained aurantosides have been tested against five fungal strains (four Candida and one Fusarium) responsible of invasive infections in immuno-compromised patients. The non-cytotoxic aurantoside I (4) was the single compound to show an excellent potency against all the tested strains, thus providing valuable insights about the antifungal potential of this class of compounds and the structure-activity relationships. 
ISSN : 1660-3397 
Journal Name : Marine Drugs 
Volume : 9 
Issue Number : 12 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Monday, March 12, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
رحاب فؤاد عنقاويAngawi, Rihab FResearcherDoctoraterangawi@kau.edu.sa
Giorgio BavestrelloBavestrello, Giorgio ResearcherDoctorate 

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