Document Details
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Document Type |
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Article In Journal |
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Document Title |
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Modulatory effect of cod-liver oil on Na+-K+ ATPase in rats' brain Modulatory effect of cod-liver oil on Na+-K+ ATPase in rats' brain |
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Subject |
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Biochemistry |
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Document Language |
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English |
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Abstract |
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Omega-3 fatty acids were used in the treatment of psychiatric diseases such as bipolar disorder. Na+, K+-ATPase is also a well-known target for these fatty acids. In this study, we investigated the impact of cod-liver oil (CLO), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on Na+, K+-ATPase, cholinesterase activities, the levels of norepinephrine (NE) and acetylcholine in different regions of rat brain. Our results showed that DHA caused a significant depression in cerebellum Na +, K+-ATPase, whereas CLO activated it. In addition, CLO, EPA and DHA produced a significant activation in Na+, K +-ATPase activity in medulla, midbrain and hypothalamus. There were non-significant changes in the activity of cholinesterase enzyme in cerebellum and medulla, while in midbrain and hypothalamus the CLO, DHA and EPA enhanced the activity by 75%, 100% and 78%, respectively. The content of NE in hypothalamus showed slight increase in different regions of the brain of animals fed CLO, DHA or EPA. In conclusion, CLO, DHA or EPA supplementation had a beneficial effect that associated with a normalization of fatty acids incorporation into phospholipid membranes and a partial restoration of Na +, K+-ATPase activity, suggesting that CLO supplementation may improve fatty acid composition and moderately enhance Na+, K+-ATPase activity. |
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ISSN |
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0960-3271 |
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Journal Name |
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Human and Experimental Toxicology |
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Volume |
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30 |
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Issue Number |
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4 |
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Publishing Year |
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1432 AH
2011 AD |
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Article Type |
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Article |
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Added Date |
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Wednesday, February 15, 2012 |
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Researchers
| طه عبدالله قمصاني | Kumosani, Taha Abdullah | Researcher | Doctorate | tkumosani@kau.edu.sa |
| سعيد سلامة مصيلحي | Moselhy, Said S | Researcher | Doctorate | Moselhy6@hotmail.com |
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