Document Details

Document Type : Article In Journal 
Document Title :
Modulatory effect of cod liver oil on bone mineralization in overiectomized female Sprague Dawley rats
Modulatory effect of cod liver oil on bone mineralization in overiectomized female Sprague Dawley rats
 
Subject : Biochemistry 
Document Language : English 
Abstract : Osteoporosis represents a major public health problem through its association with fragility fractures, primarily of the hip, spine and distal forearm. The risk of osteoporosis increased in postmenopausal women due to decline in estrogen levels. Replicable hormone therapy is associated with undesirable side effects. Cod liver oil (CLO) is a rich source of docosahexaenoic acid eicosapentaenoic acid linolenic acid and vitamins A, E and D. In this study, the effect of CLO will be tested in the prevention of bone loss in the ovariectomized (OVX) female rats. One group of OVX rats (n = 12) received an estrogen implantation at the time of operation and the second group was supplemented orally with CLO (200 μl/kg body weight) daily for 8 weeks. At the end of the experiment, blood was analysed for serum calcium, phosphorous, bone-specific alkaline phosphatase, osteocalcin and estrogen and femur for calcium determination. Estrogen implantation as well as CLO supplementation in OVX rats increased the calcium level in femur as compared with sham rats (p < 0.05). It is concluded that supplementation of CLO have a positive effect on bone mineralization in rat, and this could offer a new strategy to avoid the side effects of replaceable hormonal therapy. 
ISSN : 0748-2337 
Journal Name : Toxicology and Industrial Health 
Volume : 27 
Issue Number : 10 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Sunday, December 25, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سعيد سلامة مصيلحيMoselhy, Said SResearcherDoctorateMoselhy6@hotmail.com
عبدالرحمن لبيد المالكيAl-Malki, Abdulrahman LResearcherDoctoratealalmalki@kau.edu.sa
طه عبدالله قمصانيKumosani, Taha AbdullahResearcherDoctoratetkumosani@kau.edu.sa
جلال الدين أعظم جلالJalal, Jalaluddin AResearcherDoctoratejjalal@kau.edu.sa

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