Document Details

Document Type : Article In Journal 
Document Title :
Thermal stability of thiazide and related diuretics during superheated water chromatography
Thermal stability of thiazide and related diuretics during superheated water chromatography
 
Subject : Chemistry 
Document Language : English 
Abstract : The separations of eleven thiazide and related sulfonamide diuretics using superheated water chromatography at up to 200 °C on an XBridge C18 column were compared with conventional liquid chromatography at ambient temperature. Most of the sulfonamide diuretics were thermally stable, but many of the thiazides were degraded. The most sensitive were the dihydrothiazides, including cyclopenthiazide and hydrochlorothiazide, which were converted to the corresponding aminobenzenedisulfonamides in the pre-column heater. The N-methyl thiazides, including methyclothiazide, appeared to be more stable but degraded on the column and of the thiazides, chlorothiazide eluted largely unchanged although some on-column degradation was observed for benzthiazide. The results confirmed that in superheated water chromatography problems may be encountered with analytes with low storage stability at ambient temperature. 
ISSN : 0009-5893 
Journal Name : Chromatographia 
Volume : 72 
Issue Number : 11 
Publishing Year : 1431 AH
2010 AD 
Article Type : Article 
Added Date : Saturday, October 29, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
G HuangHuang, G ResearcherDoctorate 
R M SmithSmith, R MResearcherDoctorater.m.smith@lboro.ac.uk
حسن مبروك البشريAlbishri, Hassan MResearcherDoctoratehmalbeshri@kau.edu.sa
JinMing LinLin, JinMing ResearcherDoctorate 

Files

File NameTypeDescription
 31179.pdf pdfAbstract

Back To Researches Page