Document Details

Document Type : Article In Journal 
Document Title :
Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats
Mechanisms of the antihyperglycemic activity of Retama raetam in streptozotocin-induced diabetic rats
 
Subject : Biological 
Document Language : English 
Abstract : Retama raetam (RR) fruits are used in Saudi traditional medicine for the treatment of diabetes. Current study aimed at evaluating the potential and mechanisms of the antidiabetic activity of the RR methanolic extract in streptozotocin-induced diabetic rats. Oral LD50 of the extract was found to be 1995mg/kg. The extract was administered once orally to STZ-diabetic rats at three dose levels; 100, 250 or 500mg/kg/day for 4 consecutive weeks. RR extract at 250 or 500mg/kg significantly lowered blood glucose levels at the 3rd and 1st week of treatment, respectively. Meanwhile, oral glucose tolerance test indicated that the same two doses significantly lowered glucose levels at 30 and 60min after glucose challenge. Administration of RR extract at 500mg/kg/day for 4 consecutive weeks significantly increased serum insulin level. In vitro studies indicated that the extract significantly inhibits glucose absorption by rat isolated intestine. The extract neither altered glucose uptake by rat isolated psoas muscle nor the activity of hepatic microsomal glucose-6-phosphatase. In conclusion, the methanolic extract of RR improves STZ-induced diabetes in rats. This can be attributed, at least partly, to stimulating pancreatic insulin release and reducing intestinal glucose absorption. 
ISSN : 0278-6915 
Journal Name : Food and Chemical Toxicology 
Volume : 48 
Issue Number : 8 
Publishing Year : 1431 AH
2010 AD 
Article Type : Article 
Added Date : Monday, October 24, 2011 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
مرضي محمد الجندبيAlgandaby, Mardi MResearcherDoctoratemalgandaby@yahoo.com
حسن الغامديAlghamdi, Hassan ResearcherDoctorate 
أسامة محمد عاشورAshour, Osama MResearcherDoctorateashour032000@yahoo.com
أشرف بهي الدين عبد النعيمAbdel-Naim, Ashraf BResearcherDoctorateaabdelnaim@kau.edu.sa
صلاح عبد المنعم غريبGhareib, Salah AResearcherDoctoratesatteiah@yahoo.com
عصام عبدالحميد عبدالستارAbdel-Sattar, Essam AResearcherDoctorateabdelsattar@yahoo.com
عبدالرحمن سعيد آل حجرAbdulrahman, Hajar SResearcherDoctorateahajar@kau.edu.sa

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