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Document Type |
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Article In Journal |
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Document Title |
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Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4-triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4-triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents |
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Subject |
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Chemistry |
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Document Language |
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English |
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Abstract |
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Fluorinated 1,2,4-triazoles 3 and benzenesulfonyl urea and thiourea derivatives as well as their cyclic sulfonylthioureas 4-10 were prepared as antimicrobial agents. The chemistry involves the condensation of sulfanilamide derivatives 1 with trifluoroacetic anhydride to give N-di(trifluoroacetyl)sulfonamides 2 which upon reaction with hydrazine hydrate afforded the corresponding triazole derivatives 3. Reaction of triazole derivative 3a with isocyanates and isothiocyanates gave the corresponding ureas 4 and thioureas 5. Cyclization of thiourea derivatives with ethyl bromoacetate, 1,2-diiodoethane, diethyl oxalate and α-bromoacetophenone derivatives yielded the corresponding 4-oxothiazolidines 7, thiazolidines 8, 4,5-dioxothiazolidines 9 and thiazolines 10. Preliminary biological screening of the prepared compounds revealed significant antimicrobial and mild antidiabetic activities. |
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ISSN |
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0022-1139 |
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Journal Name |
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Journal of Fluorine Chemistry |
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Volume |
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132 |
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Issue Number |
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11 |
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Publishing Year |
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1432 AH
2011 AD |
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Article Type |
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Article |
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Added Date |
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Monday, September 26, 2011 |
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Researchers
| حسن مصطفى فيض الله | Faidallah, Hassan Mostafa | Researcher | Doctorate | HFAIDALLAH@kau.edu.sa |
| خالد خان | Khan, Khalid A | Researcher | Doctorate | |
| عبدالله محمد عسيري | Asiri, Abdullah Mohamed | Researcher | Doctorate | aasiri2@kau.edu.sa |
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