Document Details

Document Type : Article In Journal 
Document Title :
Role of natural radiosensitizers and cancer cell radioresistance: An update
Role of natural radiosensitizers and cancer cell radioresistance: An update
 
Document Language : English 
Abstract : Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomicDNAcells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up. Reactive oxygen species play an important role in different physiological processes. ROS scavenging is responsible for regulation of reactive oxygen species generation. A researcher has proved that microRNAs regulate tumor radiation resistance. Ionizing radiation does not kill the cancer cells; rather, IR just slows down the signs and symptoms. Ionizing radiation damages DNA directly/indirectly. IR is givenmostly in combination with other chemo/radiotherapies.We briefly described here the behavior of cancer stem cells and radioresistance therapies in cancer treatment. To overcome radioresistance in treatment of cancer, strategies like fractionation modification, treatment in combination, inflammation modification, and overcoming hypoxic tumor have been practiced. Natural radiosensitizers, for example, curcumin, genistein, and quercetin, are more beneficial than synthetic compounds. 
ISSN : 2210-7177 
Journal Name : Analytical Cellular Pathology 
Volume : 2016 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Tuesday, July 11, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Arif MalikMalik, Arif ResearcherDoctorate 
Misbah SultanaSultana, Misbah ResearcherDoctorate 
Aamer QaziQazi, Aamer ResearcherDoctorate 
Mahmood Husain QaziQazi, Mahmood HusainResearcherDoctorate 
Gulshan ParveenParveen, Gulshan ResearcherDoctorate 
Sulayman WaquarWaquar, Sulayman ResearcherDoctorate 
Abdul Basit AshrafAshraf, Abdul Basit ResearcherDoctorate 
Mahmood RasoolRasool, Mahmood ResearcherDoctorate 

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