Document Details

Document Type : Article In Journal 
Document Title :
Consanguinity in Saudi Arabia: a unique opportunity for pediatric kidney research
Consanguinity in Saudi Arabia: a unique opportunity for pediatric kidney research
 
Document Language : English 
Abstract : Identification of disease-related genes is a critical step in understanding the molecular basis of disease and developing targeted therapies. The genetic study of diseases occurring in the offspring of consanguineous unions is a powerful way to discover new disease genes. Pediatric nephrology provides an excellent example because ∼70% of cases of kidney disease in childhood are congenital with a likely genetic basis. This percentage is likely to be even higher in countries with a high consanguinity rate, such as the Kingdom of Saudi Arabia. However, there are a number of challenges, such as cultural, legal, and religious restrictions, that should be appreciated before carrying out genetic research in a tradition-bound country. In this article, we discuss the background, opportunities, and challenges involved with this unique opportunity to conduct studies of such genetic disorders. Keys to success include collaboration and an understanding of local traditions and laws 
ISSN : 0272-6386 
Journal Name : American Journal of Kidney Diseases 
Volume : 63 
Issue Number : 2 
Publishing Year : 1435 AH
2014 AD 
Article Type : Article 
Added Date : Tuesday, March 8, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Jameela A KariKari, Jameela A Investigator jkari@doctors.org.uk
Detlef BockenhauerBockenhauer, Detlef Researcher  
Horia StanescuStanescu, Horia Researcher  
Mamdooh GariGari, Mamdooh Researcher  
Robert KletaKleta, Robert Researcher  
Ajay K SinghSingh, Ajay K Researcher  

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