Document Details

Document Type : Article In Journal 
Document Title :
Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice
Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice
 
Document Language : English 
Abstract : Study of heavy ion radiation-induced effects on mice could provide insight into the human health risks of space radiation exposure. The purpose of the present study is to assess the relative biological effectiveness (RBE) of (12)C and (28)Si ion radiation, which has not been reported previously in the literature. Female C57BL/6J mice (n = 15) were irradiated using 4-8 Gy of (28)Si (300 MeV/nucleon energy; LET 70 keV/μm) and 5-8 Gy of (12)C (290 MeV/nucleon energy; LET 13 keV/μm) ions. Post-exposure, mice were monitored regularly, and their survival observed for 30 days. The LD(50/30) dose (the dose at which 50 % lethality occurred by 30-day post-exposure) was calculated from the survival curve and was used to determine the RBE of (28)Si and (12)C in relation to γ radiation. The LD(50/30) for (28)Si and (12)C ion is 5.17 and 7.34 Gy, respectively, and the RBE in relation to γ radiation (LD(50/30)-7.25 Gy) is 1.4 for (28)Si and 0.99 for (12)C. Determination of RBE of (28)Si and (12)C for survival in mice is not only important for space radiation risk estimate studies, but it also has implications for HZE radiation in cancer therapy. 
ISSN : 0301-634X 
Journal Name : Radiation and environmental biophysics 
Volume : 51 
Issue Number : 3 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Tuesday, March 8, 2016 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Shubhankar SumanSuman, Shubhankar Investigator  
Kamal DattaDatta, Kamal Researcher  
Daniela TraniTrani, Daniela Researcher  
Evagelia C LaiakisLaiakis, Evagelia C Researcher  
Steven J StrawnStrawn, Steven J Researcher  
Albert J Fornace JrFornace Jr, Albert J Researcher  

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